Heart health
Left bundle-branch pacing outperforms right ventricular pacing in trial
In OptimPacing, the composite outcome occurred in 16 patients assigned to left bundle-branch pacing and 35 assigned to right ventricular pacing.
The OptimPacing trial found that left bundle-branch pacing was superior to right ventricular pacing for patients with atrioventricular block who needed a pacemaker. Researchers presented the findings at the American Heart Association Scientific Sessions, and the study was published in The New England Journal of Medicine.
The trial enrolled 702 patients, and 685 were included in the modified intention-to-treat analysis. At a median follow-up of 35.1 months, 16 patients in the left bundle-branch pacing group and 35 in the right ventricular pacing group had a primary outcome of death from any cause, heart failure hospitalization or pacing-induced cardiomyopathy. The reported 4-year cumulative incidence was 8.5% versus 19.2%. Researchers stopped the trial early after an interim analysis found left bundle-branch pacing superior.
